Preparation of Furan from cis-2-Butene-1,4-diol.
نویسندگان
چکیده
منابع مشابه
Detection of DNA adducts derived from the reactive metabolite of furan, cis-2-butene-1,4-dial.
Furan is a toxic and carcinogenic compound used in industry and commonly found in the environment. The mechanism of furan's carcinogenesis is not well-understood and may involve both genotoxic and nongenotoxic pathways. Furan undergoes oxidation by cytochrome P450 to cis-2-butene-1,4-dial, which is thought to mediate furan's toxic effects. Consistently, cis-2-butene-1,4-dial readily reacts with...
متن کاملLINEAR ALIPHATIC UNSATURATED POLYESTERS BASED ON CIS -2- BUTENE -1,4-DIOL: SYNTHESIS AND CHARACTERIZATION
A new homologous series of linear aliphatic polyesters, such as poly (cis-2- butenylene carboxylate)S, PBms (m is the number of methylene groups in the acid component, m=2-8 have been synthesized by direct polyesterification reactions in anisole, as solvent. FT-IR, 400 MHz H- NMR, C-NMR and elemental analysis were used to establish the structure of polyesters. Molecular weight distributi...
متن کاملGlutathione trapping to measure microsomal oxidation of furan to cis-2-butene-1,4-dial.
Furan is a liver carcinogen and toxicant. Furan is oxidized to the reactive dialdehyde, cis-2-butene-1,4-dial, by microsomal enzymes. This reactive metabolite readily reacts with glutathione nonenzymatically to form conjugates. A high-performance liquid chromatography-electrochemical method for the detection of cis-2-butene-1,4-dial-glutathione (GSH) conjugates in microsomal preparations was de...
متن کاملlinear aliphatic unsaturated polyesters based on cis -2- butene -1,4-diol: synthesis and characterization
a new homologous series of linear aliphatic polyesters, such as poly (cis-2- butenylene carboxylate)s, pbms (m is the number of methylene groups in the acid component, m=2-8 have been synthesized by direct polyesterification reactions in anisole, as solvent. ft-ir, 400 mhz h- nmr, c-nmr and elemental analysis were used to establish the structure of polyesters. molecular weight distributions wer...
متن کاملTrapping of cis-2-butene-1,4-dial to measure furan metabolism in human liver microsomes by cytochrome P450 enzymes.
Furan is a liver toxicant and carcinogen in rodents. It is classified as a possible human carcinogen, but the human health effects of furan exposure remain unknown. The oxidation of furan by cytochrome P450 (P450) enzymes is necessary for furan toxicity. The product of this reaction is the reactive α,β-unsaturated dialdehyde, cis-2-butene-1,4-dial (BDA). To determine whether human liver microso...
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1961
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.15-1177